Substance Identity
CAS Number 68-12-2
Chemical Name Formamide, N,N-dimethyl-
Type of substance Organic
SMILES O=CN(C)C
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? No
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 4.4
Reference (biodegradation result) CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992
Robust Study Summary (biodegradation result)
MITI book - P data.doc
Predicted Ultimate degradation half-life (days) 15
MITI probability of biodegradation 0.7925
TOPKAT probability of biodegradation 0.375
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.6102

Underlying data regarding Bioaccumulation

Empirical Log Kow -1.01
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin -0.93
Log BAF T2MTL predicted by Gobas -0.0255970749591207
Log BCF 5% T2LTL predicted by Gobas -0.0201624278724784
Log BCF Max predicted by OASIS 0.972963700358917
Log BCF predicted by BCFWIN 0.5
Experimental BCF (log) -0.192399255560819
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 20
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 56
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 12500
Experimental result iT (mg/l) 12500
Exposure duration iT (hours) 48
Robust Study Summary iT
68122-AT-LC50-I-dapmag.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 35.8
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 30,767.346
Toxicity to fish (LC50 in mg/l) as predicted by PNN 4,738.94393
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 12,000
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 14,221.323
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 383.257
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 3.08E+002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Previous assessment through previous CEPA assessment

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
EC Developmental - Category 2

Underlying data regarding Complex Hazard Assessment