Substance Identity
CAS Number 80-05-7
Chemical Name Phenol, 4,4 -(1-methylethylidene)bis-
Type of substance Organic
SMILES Oc(ccc(c1)C(c(ccc(O)c2)c2)(C)C)c1
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? No
Persistent (P)? No
Rational for P Category
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water-Soil
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 0
Reference (biodegradation result) CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992
Robust Study Summary (biodegradation result)
80057.doc
MITI book - P data.doc
Predicted Ultimate degradation half-life (days) 37.5
MITI probability of biodegradation 0.1559
TOPKAT probability of biodegradation 0
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.1327

Underlying data regarding Bioaccumulation

Empirical Log Kow 3.32
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 3.64
Log BAF T2MTL predicted by Gobas 0.718194687739699
Log BCF 5% T2LTL predicted by Gobas 0.716272147471701
Log BCF Max predicted by OASIS 2.98048987943258
Log BCF predicted by BCFWIN 1.856
Experimental BCF (log) 1.3014833444934
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 150
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 42
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 1
Experimental result iT (mg/l) 1
Exposure duration iT (hours) 72
Robust Study Summary iT
80057_CT_mediansurvivaltime_V_Rantem.doc
80057-AT-LC50-F-Xiphel.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 4.3
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 3.275
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 7.2217
Toxicity to fish (LC50 in mg/l) as predicted by Aster 4.797763
Toxicity to fish (LC50 in mg/l) as predicted by PNN 8.47996
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 5.2
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 4.01
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 4.86E-002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
EC Reproductive - Category 3

Underlying data regarding Complex Hazard Assessment