Substance Identity
CAS Number 1336-36-3
Chemical Name 1,1'-Biphenyl, chloro derivs.
Type of substance Organic
SMILES Clc2c(ccc(c2)Cl)c1c(cc(cc1)Cl)Cl
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? Yes
Rational for P QSAR
Bioaccumulative (B)? Yes
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) 0 to 1T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? PBiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Soil
Experimental Biodegradation half-life (days) Not Available
Robust Study Summary (biodegradation result)
1336363.doc
Predicted Ultimate degradation half-life (days) 182
MITI probability of biodegradation 0.0023
TOPKAT probability of biodegradation 0
EPI Predicted Ozone reaction half-life (days) 999
Experimental Atmospheric Oxidation half-life (days) 10.6944444444444
Reference (oxidation) ATKINSON,R.; KINETICS AND MECHANISMS OF THE GAS-PHASE REACTIONS OF THE HYDROXYL RADICAL WITH ORGANIC COMPOUNDS.; JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA. MONOGRAPH NO. 1.; 1989
EPI Predicted Atmospheric Oxidation half-life (days) 13.15

Underlying data regarding Bioaccumulation

Empirical Log Kow 6.29
Reference (Log Kow) EPISUITE KOWWIN v1.67
Log Kow predicted by KowWin 6.34
Log BAF T2MTL predicted by Gobas 6.02171549440391
Log BCF 5% T2LTL predicted by Gobas 4.57199039076052
Log BCF Max predicted by OASIS 4.82915694823458
Log BCF predicted by BCFWIN 4.763
Experimental BAF (log) 7.3
Reason for pivotal value Highest Vertebrate BAF (Surrogate for all PCB congeners)
Test species BCF/BAF (Latin) Micropterus salmoides
Test species BCF/BAF (Common) Largemouth bass
Mean water concentration (ug/l) 0.000001
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (comment) Lifetime exposure; assumed steady state
Exposure type Lentic
Mean temperature (deg. Celcius) 12
Exposure route Water & Diet
Exposure media Fresh Water
Mean measured lipid content (%) 3.1
Tissue analysed Muscle
Calculation method Cb/Cw
Comment (BAF/BCF) 2,2',3,4,4',5',6-Heptachloro-1,1'-biphenyl (CAS# 52663-69-1) selected as surrogate for polychlorinated biphenyls; Average BAF - Western Lake Erie
Reference (BAF/BCF) Morrison, H.A., F.A.P.C. Gobas, Lazar, R., Whittle, D.M. and G.D. Haffner. 1997. Development and verification of a benthic/pelagic food web bioaccumulation model for PCB congeners in Wester Lake Erie. Environ. Sci. Technol. 31:3267-3273

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.005
Experimental result iT (mg/l) 0.005
Test species iT (Latin) Selenastrum capricornutum
Test species iT (Common) Green algae
Final EndPoint iT EC50
Exposure duration iT (hours) 48
Reference iT Mayer, P., B. Halling-Sorensen, D. T.H.M. Sigm and N. Nyholm. 1998. Toxic cell concentrations of three polychlorinated biphenyl congeners in the green alga Selenastrum capricornutum. Environ. Toxicol. Chem. 17(9): 1848-1851.
Robust Study Summary iT
1336363_AT_48hEC50_selcap.doc
1336363 - AT - 48 hr - algae - Thapse.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 0.0883
Toxicity to fish (LC50 in mg/l) as predicted by PNN 0.17237
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.021
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 0.009
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 6.50E-004

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Previous assessment through CEPA Toxic Substances List (Schedule 1)

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
IARC Carcinogenicity - Group 2A
NTP Carcinogenicity - Reasonably anticipated to be a human carcinogen
USEPA 1986 Carcinogenicity - Groups B1 and B2

Underlying data regarding Complex Hazard Assessment