Substance Identity
CAS Number 67-66-3
Chemical Name Methane, trichloro-
Type of substance Organic
SMILES C(Cl)(Cl)Cl
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? PiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air
Experimental Biodegradation half-life (days) Not Available
Predicted Ultimate degradation half-life (days) 37.5
MITI probability of biodegradation 0.0503
TOPKAT probability of biodegradation 0
EPI Predicted hydrolysis half-life (days) 1.25E+006
EPI Predicted Ozone reaction half-life (days) 999
Experimental Atmospheric Oxidation half-life (days) 103.829557713053
Reference (oxidation) ATKINSON,R.; KINETICS AND MECHANISMS OF THE GAS-PHASE REACTIONS OF THE HYDROXYL RADICAL WITH ORGANIC COMPOUNDS.; JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA. MONOGRAPH NO. 1.; 1989
EPI Predicted Atmospheric Oxidation half-life (days) 100.5

Underlying data regarding Bioaccumulation

Empirical Log Kow 1.97
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 1.52
Log BAF T2MTL predicted by Gobas 0.426348230360381
Log BCF 5% T2LTL predicted by Gobas 0.408032265195973
Log BCF Max predicted by OASIS 1.4542887572182
Log BCF predicted by BCFWIN 0.817
Experimental BCF (log) 0.705940215277707
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 1,000
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 42
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Mean measured lipid content (%) 2.8
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.27
Experimental result iT (mg/l) 0.27
Exposure duration iT (hours) 168
Robust Study Summary iT
67663-AT-LC50-O-hylcru.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 141
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 250.106
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 440.4727
Toxicity to fish (LC50 in mg/l) as predicted by Aster 98.746578
Toxicity to fish (LC50 in mg/l) as predicted by PNN 34.62322
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 51.9
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 101.607
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 10.778
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 2.50E+002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Previous assessment through previous CEPA assessment

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
HC Carcinogenicity - Group II
USEPA 2003 Carcinogenicity - Likely to be carcinogenic to humans
NTP Carcinogenicity - Reasonably anticipated to be a human carcinogen
IARC Carcinogenicity - Group 2B
EC Carcinogenicity - Category 3
USEPA 1986 Carcinogenicity - Groups B1 and B2

Underlying data regarding Complex Hazard Assessment