Substance Identity
CAS Number 65277-42-1
Chemical Name Piperazine, 1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel-
Type of substance Organic
SMILES CC(=O)N(C1)CCN(C1)c(c2)ccc(c2)OCC(CO3)OC3(Cn4cncc4)c5c(Cl)cc(Cl)cc5
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? No
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P QSAR
Bioaccumulative (B)? No
Rational for B QSAR
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT QSAR
DSL Quantity range (tonnes/year) Unknown Quantity

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Predicted Ultimate degradation half-life (days) 182
MITI probability of biodegradation 0.0002
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.04531

Underlying data regarding Bioaccumulation

Empirical Log Kow 4.35
Log Kow predicted by KowWin 4.45
Log BAF T2MTL predicted by Gobas 3.30227242161008
Log BCF 5% T2LTL predicted by Gobas 3.05122295858307
Log BCF Max predicted by OASIS 3.75071538190783
Log BCF predicted by BCFWIN 2.65

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 2.2862
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 3.958
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 2.2862
Toxicity to fish (LC50 in mg/l) as predicted by PNN 26.93838
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.401
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 1.96E-002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment