Canadian Categorization Results

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Substance Identity

Categorization Results

Meets Government of Canada Categorization Criteria?	No
Meets Human Health Categorization Criteria?	No
Meets Environmental Criteria for Categorization?	No
Persistent (P)?	Yes
Rational for P	Experiment
Bioaccumulative (B)?	No
Rational for B	Experiment
Inherently Toxic to Aquatic Organisms (iT)?	No
Rational for iT	Experiment
DSL Quantity range (tonnes/year)	>1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization	Air
Experimental Biodegradation half-life (days)	Not Available
Predicted Ultimate degradation half-life (days)	37.5
MITI probability of biodegradation	0.0408
TOPKAT probability of biodegradation	0
EPI Predicted Ozone reaction half-life (days)	2,239
Experimental Atmospheric Oxidation half-life (days)	4.53154425612053
Reference (oxidation)	ATKINSON,R.; KINETICS AND MECHANISMS OF THE GAS-PHASE REACTIONS OF THE HYDROXYL RADICAL WITH ORGANIC COMPOUNDS.; JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA. MONOGRAPH NO. 1.; 1989
EPI Predicted Atmospheric Oxidation half-life (days)	13.29

Underlying data regarding Bioaccumulation

Empirical Log Kow	2.42
Reference (Log Kow)	HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin	2.47
Log BAF T2MTL predicted by Gobas	0.422873210678187
Log BCF 5% T2LTL predicted by Gobas	0.417638529524858
Log BCF Max predicted by OASIS	1.99127076798661
Log BCF predicted by BCFWIN	1.163
Experimental BCF (log)	1.01129279804471
Reason for pivotal value	Highest Average Vertebrate BCF
Test species BCF/BAF (Latin)	Cyprinus carpio
Test species BCF/BAF (Common)	Common carp
Mean water concentration (ug/l)	7
Mean water concentration (comment)	Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain	Measured
RadioLabel	No
Exposure duration (days)	42
Exposure duration (comment)	Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type	Flow-through
Mean temperature (deg. Celcius)	22
Exposure route	Water (but fed)
Exposure media	Fresh Water
Tissue analysed	Whole body
Calculation method	Cb/Cw
Comment (BAF/BCF)	Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF)	Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l)

3.1

Experimental result iT (mg/l)

3.1

Exposure duration iT (hours)

Robust Study Summary iT

Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1

108.4

Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10

52.4018

Toxicity to fish (LC50 in mg/l) as predicted by Aster

25.749729

Toxicity to fish (LC50 in mg/l) as predicted by PNN

30.05619

Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1

Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g

27.422

Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g

3.52E+001

Human Health data supporting decisions

Underlying data regarding potential for exposure

LPE/IPE/GPE

Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Previous assessment through

previous CEPA assessment

Underlying data regarding Simple Hazard Assessment

Agency	Assessment
IARC	Carcinogenicity - Group 2A
NTP	Carcinogenicity - Reasonably anticipated to be a human carcinogen
HC	Carcinogenicity - Groups IIIA and IIIB
EC	Carcinogenicity - Category 2
EC	Genotoxicity - Category 3

Underlying data regarding Complex Hazard Assessment