Substance Identity
CAS Number 130-61-0
Chemical Name 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride
Type of substance Organic
SMILES N(C(CCC1)CCN(c(c(Sc2cccc3)ccc4SC)c4)c23)(C1)C
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? No
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? Uncertain
Persistent (P)? No
Rational for P QSAR
Bioaccumulative (B)? Uncertain
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) Unknown Quantity

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Predicted Ultimate degradation half-life (days) 60
MITI probability of biodegradation 0.0007
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.04168

Underlying data regarding Bioaccumulation

Log Kow predicted by KowWin 4.93
Log BAF T2MTL predicted by Gobas 4.12059542583135
Log BCF 5% T2LTL predicted by Gobas 3.61255008232469
Log BCF Max predicted by OASIS 2.34141032230565
Log BCF predicted by BCFWIN 0.5

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.706
Experimental result iT (mg/l) 0.706
Test species iT (Latin) Daphnia pulex
Test species iT (Common) Water flea
Final EndPoint iT EC50
Exposure duration iT (hours) 24
Reference iT Lilius, H., Hastbacka, T. & B. Isomaa. 1995. A comparison of the toxicity of 30 reference chemicals to Daphnia magna and Daphnia pulex. Environmental Toxicology and Chemistry. 14(12):2085-2088.
Robust Study Summary iT
130610-AT-24hEC50-daphnids.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 0.0086
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 0.145
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.066
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 6.62E-004

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment